Phenotypes for Rheb Tsc1 MGI:4949084 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rheb^tm1.1Yelg/Rheb⁺ Tsc1^tm1Chdl/Tsc1^tm1Chdl
Genetic Background	B6.129P2-Tsc1^tm1Chdl Rheb^tm1.1Yelg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rheb^tm1.1Yelg mutation (0 available); any Rheb mutation (26 available)
Tsc1^tm1Chdl mutation (0 available); any Tsc1 mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:170999 )

• mice die between E15.5 and birth unlike Tsc1^tm1Chdl heterozygotes which die between E10.5 and E13.5

growth/size/body

decreased fetal size ( J:170999 )

• at E15.5

fetal growth retardation ( J:170999 )

• at E15.5

cellular

increased embryonic tissue cell apoptosis ( J:170999 )

• in E15.5 embryos

embryo

increased embryonic tissue cell apoptosis ( J:170999 )

• in E15.5 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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