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Phenotypes Associated with This Genotype
Genotype
MGI:4949667
hm1
Allelic
Composition		 Tktl1tm1Arte/Tktl1tm1Arte
Genetic
Background		 C57BL/6-Tktl1tm1Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tktl1tm1Arte mutation (1 available); any Tktl1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:171154 )
• DSS-treated mice exhibit severe mucosal damage, total loss of crypt structure, worsened inflammation, shorter colon, increased histological score, increased body weight loss, and enhanced myeloperoxidase activity compared with similarly treated wild-type mice

growth/size/body
increased susceptibility to weight loss ( J:171154 )
• in DSS-treated mice

immune system
increased susceptibility to induced colitis ( J:171154 )
• DSS-treated mice exhibit severe mucosal damage, total loss of crypt structure, worsened inflammation, shorter colon, increased histological score, increased body weight loss, and enhanced myeloperoxidase activity compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory