Phenotypes Associated with This Genotype

Genotype
MGI:4949888

• Allelic Composition: Mecp2^tm1Vnar/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Frontal cortex and olfactory bulbs of Mecp2^tm1Vnar/Y mice exhibit an increase in cell density

mortality/aging

mortality/aging ( J:171410 )

♂N • mice live longer than 14 months with no unusual health issues

reproductive system

male infertility ( J:171410 )

♂ • mice do not successfully reproduce

nervous system

abnormal hippocampus morphology ( J:171410 )

♂ • cell density in the CA1, CA2, and CA3 of the hippocampus is increased compared to in wild-type mice

abnormal dentate gyrus morphology ( J:171410 )

♂ • cell density in the dentate gyrus is increased compared to in wild-type mice

abnormal orbitofrontal cortex morphology ( J:171410 )

♂ • cell density in the frontal cortex is increased compared to in wild-type mice

abnormal olfactory bulb morphology ( J:171410 )

♂ • cell density in the olfactory bulb is increased compared to in wild-type mice

abnormal cerebellum morphology ( J:171410 )

♂ • cell density in the cerebellum is increased compared to in wild-type mice

abnormal cerebellar granule layer morphology ( J:171410 )

♂ • cell density in the granule cell layer of the cerebellum is increased compared to in wild-type mice

abnormal dendrite morphology ( J:171410 )

♂ • cortical neurons exhibit abnormal dendritic branching and decreased dendritic complexity compared with wild-type neurons

behavior/neurological

behavior/neurological phenotype ( J:171410 )

♂N • mice do not exhibit seizures or tremors

growth/size/body

growth/size/body region phenotype ( J:171410 )

♂N • mice exhibit normal weight gain

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:171410