vision/eye
N |
• no differences in eye electrophysiology or signs of photoreceptor degeneration are detected in mice at up to 24 months of age
|
• loss of the basal infoldings and accumulation of amorphous deposits between the RPE and Bruch's membrane are seen at 24 months of age
• vacuoles are present in the RPE at 24 months of age
• changes in the RPE are more severe in homozygous mice compared to heterozygous mice
|
• late onset degeneration of the retinal pigment epithelium
|
pigmentation
• loss of the basal infoldings and accumulation of amorphous deposits between the RPE and Bruch's membrane are seen at 24 months of age
• vacuoles are present in the RPE at 24 months of age
• changes in the RPE are more severe in homozygous mice compared to heterozygous mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
retinitis pigmentosa 13 | DOID:0110403 |
OMIM:600059 |
J:171561 |