Analysis Tools
mortality/aging
 N |
• mice survive to at least 80 weeks of age
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behavior/neurological
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N |
• mice show similar grooming times to controls
• mice have a nonsignificant trend to reduced total distance traveled
• time exhibiting aggressive behavior such as wrestling, tail-rattling, boxing, and mounting is similar to controls
• mice exhibit intact olfactory recognition and habituation in response to a novel odorant at 11 weeks of age
• at 12 weeks, mice have intact nociception demonstrated by a hot-plate or tail-flick assay
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• mice show impaired maximum acoustic startle response to 120dB
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• mice display more footslips, shorter latency to fall on wire, reduced number of side touches on dowel and shorter latency to fall from rotarod compared to controls
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• mice show a 200% increase relative to control in number of holes explored with 2 or more sequential nose pokes in a holeboard assay
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• nest building is impaired
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• mice show increased social interaction with novel and familiar partners; time spent with novel partners is 60% higher than in controls in a 3-chamber assay
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nervous system
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• 24 week-old mice show increased prepulse inhibition at 74 dB
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respiratory system
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N |
• mice show no alterations in tidal volume or minute volume, and display no apneas
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