Analysis Tools
mortality/aging
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• 50% of mice die postnatally
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behavior/neurological
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• mice spend less time with a novel object compared with wild-type mice
• however, amphetamine treatment normalizes impaired memory
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• in a Morris water maze, mice exhibit impaired learning compared with wild-type mice
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• mice exhibit reduced swimming velocity compared with wild-type mice
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• 2-fold in an open field at 8 weeks of age
• in a home cage at 8 weeks of age
• however, 7 month old mice exhibit normal locomotor activity and amphetamine-treatment normalizes hyperactivity
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nervous system
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• the number of parvalbumin neurons in the hippocampal area and cortex is reduced compared to in wild-type mice
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• mice exhibit enhanced theta rhythms compared with wild-type mice
• however, amphetamine treatment reversed elevated theta rhythms
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• the ratio of field excitatory postsynpatic potential slopes to fiber volley amplitudes is increased compared to in wild-type mice
• however, presynaptic release probability is normal
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• mice exhibit decreased miniature inhibitory postsynaptic current (mIPSC) frequency compared with wild-type mice
• however, mIPSC amplitude is normal
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growth/size/body
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• in surviving mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| attention deficit hyperactivity disorder | DOID:1094 |
OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 |
J:171608 | |
