Phenotypes for Boc Cdon MGI:5000248 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Boc^tm1Rsk/Boc^tm1Rsk Cdon^tm1Rsk/Cdon^tm1Rsk
Genetic Background	B6.129-Boc^tm1Rsk Cdon^tm1Rsk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Boc^tm1Rsk mutation (0 available); any Boc mutation (61 available)
Cdon^tm1Rsk mutation (0 available); any Cdon mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

holoprosencephaly ( J:171767 )

• display a range of holoprosencephalic phenotypes

craniofacial

craniofacial phenotype ( J:171767 )

N	• do not display cyclopia

cleft upper lip ( J:171767 )

• Background Sensitivity: unlike mice on a 129 background, mice on a C57BL/6 background display cleft lip

proboscis ( J:171767 )

• proboscis like nose

vision/eye

ocular hypotelorism ( J:171767 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:171767 )

N	• do not display digit patterning defects unlike Shh null mice

growth/size/body

cleft upper lip ( J:171767 )

• Background Sensitivity: unlike mice on a 129 background, mice on a C57BL/6 background display cleft lip

proboscis ( J:171767 )

• proboscis like nose

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
holoprosencephaly 11		DOID:0110877	OMIM:614226	J:171767

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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