Phenotypes Associated with This Genotype

Genotype
MGI:5000280

• Allelic Composition: Tg(AR*100Q)C32Als/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:89772 )

• mice die of unknown causes at 20 to 24 months of age

behavior/neurological

abnormal gait ( J:89772 )

• at 18 months, male mice exhibit impaired gait compared with control mice

• however, female mice do not exhibit impaired gait

hindlimb paralysis ( J:89772 )

• at 22 months, male mice exhibit hindlimb paralysis unlike control mice

• however, female mice do not exhibit severe hindlimb paralysis

growth/size/body

decreased body size ( J:89772 )

• beginning at 12 months of age in male mice and 22 months of age in female mice

decreased body weight ( J:89772 )

• beginning at 12 months of age in male mice and 22 months of age in female mice

muscle

skeletal muscle atrophy ( J:89772 )

• at 18 months, male mice exhibit hindlimb atrophy unlike control mice

• however, female mice do not exhibit severe hindlimb atrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kennedy's disease		DOID:0060161	OMIM:313200	J:89772