Phenotypes Associated with This Genotype

Genotype
MGI:5000479

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)#Tfln/0; Trp53^tm1Brn/Trp53⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:170898 )

• survival is reduced compared to mutant mice wild-type for Trp53

neoplasm

increased mammary gland tumor incidence ( J:170898 )

• 80% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma

• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

increased mammary adenocarcinoma incidence ( J:170898 )

increased lymphoma incidence ( J:170898 )

• at a lower rate than in mutant mice homozygous for Trp53^tm1Brn

increased T cell derived lymphoma incidence ( J:170898 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:170898 )

increased mammary gland tumor incidence ( J:170898 )

• 80% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma

• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

increased mammary adenocarcinoma incidence ( J:170898 )

integument

increased mammary gland tumor incidence ( J:170898 )

• 80% of mice have mammary tumors

• many mice have tumors in more than one gland

• mammary tumors are either spindle/epithelial-mesenchymal transition or adenosquamous carcinoma

• radial scar and poorly differentiated adenocarcinomas are also observed, although at a lower frequency than in mutant mice not carrying Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}

increased mammary adenocarcinoma incidence ( J:170898 )

immune system

increased T cell derived lymphoma incidence ( J:170898 )

hematopoietic system

increased T cell derived lymphoma incidence ( J:170898 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:170898