Phenotypes Associated with This Genotype

Genotype
MGI:5000531

• Allelic Composition: Id1^tm1Zhu/Id1⁺; Id3^tm1Zhu/Id3^tm1Zhu
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to otitis media ( J:311050 )

• 71% of mice are affected with middle ear fluid, inflammation in the tympanic membrane and opacification of the tympanic membrane, indicating otitis media

• inflammatory cells of the effusion content are mainly polymorphonuclear cells

cardiovascular system

abnormal tumor vascularization ( J:86480 )

• injected B6RV2 and LLC tumors exhibit impaired angiogenesis compared to when tumors are injected into wild-type mice

hearing/vestibular/ear

abnormal middle ear morphology ( J:311050 )

• fibrous proliferation is seen in the middle ear space of some mice and the middle ear mucosa is thickened

middle ear effusion ( J:311050 )

• different degrees of effusion in the middle ear cavities

increased or absent threshold for auditory brainstem response ( J:311050 )

• 100% of mice exhibit high ABR thresholds for at least one stimulus frequency in at least one ear, with 92.9% for the right ears and 92.9% for the left ears

• at P30, the mean ABR thresholds at any stimulus frequency are higher than of controls and at P60, ABR thresholds at all stimulus frequencies are higher

decreased distortion product otoacoustic emission amplitude ( J:311050 )

• at P30 and P60, the DPOAE amplitudes at dominant frequencies 7,692, 10,152, 13,390, and 17,672 are lower

conductive hearing loss ( J:311050 )

• mice present hearing loss from 30 days of age at all stimulus frequencies

increased susceptibility to otitis media ( J:311050 )

• 71% of mice are affected with middle ear fluid, inflammation in the tympanic membrane and opacification of the tympanic membrane, indicating otitis media

• inflammatory cells of the effusion content are mainly polymorphonuclear cells

neoplasm

abnormal tumor vascularization ( J:86480 )

• injected B6RV2 and LLC tumors exhibit impaired angiogenesis compared to when tumors are injected into wild-type mice

decreased metastatic potential ( J:86480 )

• injected B6RV2 and LCC tumors exhibit decreased metastases compared to when tumors are injected into wild-type mice

decreased tumor growth/size ( J:86480 )

• injected B6RV2, B-CA, and LCC tumors exhibit impaired tumor growth compared to when tumors are injected into wild-type mice

tumor regression ( J:86480 )

• injected B6RV2 and B-CA tumors exhibit tumor regression compared to when tumors are injected into wild-type mice

homeostasis/metabolism

middle ear effusion ( J:311050 )

• different degrees of effusion in the middle ear cavities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:311050