Phenotypes Associated with This Genotype

Genotype
MGI:5002366

• Allelic Composition: Id1^tm1Zhu/Id1^tm1Zhu; Id3^tm1Zhu/Id3⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to otitis media ( J:311050 )

• 51% of mice are affected with middle ear fluid, inflammation in the tympanic membrane and opacification of the tympanic membrane, indicating otitis media

• inflammatory cells of the effusion content are mainly polymorphonuclear cells

hearing/vestibular/ear

abnormal middle ear morphology ( J:311050 )

• fibrous proliferation is seen in the middle ear space of some mice and the middle ear mucosa is generally thickened

middle ear effusion ( J:311050 )

• different degrees of effusion in the middle ear cavities

increased or absent threshold for auditory brainstem response ( J:311050 )

• 89.1% of mice exhibit high ABR thresholds for at least one stimulus frequency in at least one ear, with 82.2% for the right ears and 81.2% for the left ears

• at P30, the mean ABR thresholds at any stimulus frequency are higher than of controls and at P60, ABR thresholds for click and 8 kHz are highe

decreased distortion product otoacoustic emission amplitude ( J:311050 )

• at P30, the DPOAE amplitudes at dominant frequencies 7,692, 10,152, 13,390, and 17,672 are lower

• at P60, the DPOAE amplitudes at 13,390 and 17,672 are lower

conductive hearing loss ( J:311050 )

• mice present hearing loss from 30 days of age at all stimulus frequencies

increased susceptibility to otitis media ( J:311050 )

• 51% of mice are affected with middle ear fluid, inflammation in the tympanic membrane and opacification of the tympanic membrane, indicating otitis media

• inflammatory cells of the effusion content are mainly polymorphonuclear cells

homeostasis/metabolism

middle ear effusion ( J:311050 )

• different degrees of effusion in the middle ear cavities

vision/eye

vision/eye phenotype ( J:170418 )

N • retinal development are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:311050