Analysis Tools
immune system
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• 4 fold expansion in mice recovering from dermatitis at 70 days of age compared to a 28% increase in age matched controls
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• massive central depletion and peripheral neutropenia
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• thymocytes reduced 10 fold
• double positive thymocyte numbers reduced 500 fold
• single positive cells also reduced
• virtually no CD4+ cells are found in the spleen
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• mice immunized with hen egg lysozyme fail to respond to later antigen challenge
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• Background Sensitivity: response increases with increasing DBA/2 contribution to the background, varying degrees of resistance on C57BL/6 or BALB/c backgrounds
• spontaneous inflammatory skin disease develops around the time of sexual maturity, within 1- 2 weeks of weaning, earlier and more severe in males
• chronic with periodic flares, typically involves ears, rostrum, and perineum
• acute disease begins in the periocular region involving edema and serous exudate
• swelling of the pinna and hyperkeratotic debris extending into the external auditory meatus
• recovery begins around 70 days of age and recovered mice are resistant to recurrence
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integument
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• Background Sensitivity: response increases with increasing DBA/2 contribution to the background, varying degrees of resistance on C57BL/6 or BALB/c backgrounds
• spontaneous inflammatory skin disease develops around the time of sexual maturity, within 1- 2 weeks of weaning, earlier and more severe in males
• chronic with periodic flares, typically involves ears, rostrum, and perineum
• acute disease begins in the periocular region involving edema and serous exudate
• swelling of the pinna and hyperkeratotic debris extending into the external auditory meatus
• recovery begins around 70 days of age and recovered mice are resistant to recurrence
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• edematous dermal papillae
• neutrophilic abscesses
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• epidermal thickening from 1-2 layers to 10 layers
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hematopoietic system
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• 4 fold expansion in mice recovering from dermatitis at 70 days of age compared to a 28% increase in age matched controls
|
|
• massive central depletion and peripheral neutropenia
|
|
• thymocytes reduced 10 fold
• double positive thymocyte numbers reduced 500 fold
• single positive cells also reduced
• virtually no CD4+ cells are found in the spleen
|
|
• mice immunized with hen egg lysozyme fail to respond to later antigen challenge
|
endocrine/exocrine glands
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• thymocytes reduced 10 fold
• double positive thymocyte numbers reduced 500 fold
• single positive cells also reduced
• virtually no CD4+ cells are found in the spleen
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