Phenotypes Associated with This Genotype

Genotype
MGI:5003460

• Allelic Composition: Tg(Thy1-APP^SL)28Lpr/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:86694 , J:99507 )

• plaques are seen at 6 months of age (J:86694)

• detected in the hippocampus at 17 months of age (J:99507)

abnormal brain morphology ( J:95529 )

• levels of SDS-soluble amyloid beta protein are higher in females than in males at 3 months of age

abnormal hippocampus molecular cell layer ( J:99507 )

• age-related decline in mean synaptic bouton densities

abnormal hippocampus stratum radiatum morphology ( J:99507 )

• age-related decline in mean synaptic bouton densities in area CA1?2

abnormal neurite morphology ( J:86694 )

• clusters of swollen and abnormally distorted neuritic profiles are seen

abnormal synaptic bouton morphology ( J:99507 )

• age-related decline in mean synaptic bouton densities within the hippocampal molecular cell layer and stratum radiatum of area CA1?2

abnormal nervous system physiology ( J:95529 )

• elevated levels of lipid peroxidation products in brain homogenates in females at 3 months of age and in males and females at 12 months of age

• reduced levels of antioxidant enzymes at 3 and 12 months of age

abnormal neuron physiology ( J:152956 )

• impaired mitochondrial function

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:152956 )

• mitochondrial membrane potentials and ATP levels are reduced in dissociated brain cells at 3 months of age

• inhibition of complex IV and significantly reduced cytochrome c oxidase activity in cerebral isolated mitochondria

• state 3 and state 4 respiration are significantly reduced in freshly isolated cerebral mitochondria at 17 months of age

homeostasis/metabolism

amyloid beta deposits ( J:86694 , J:99507 )

• plaques are seen at 6 months of age (J:86694)

• detected in the hippocampus at 17 months of age (J:99507)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:86694 , J:99507