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Phenotypes Associated with This Genotype
Genotype
MGI:5003462
Allelic
Composition		 Tg(Hmgcr-PSEN1*M146L)#Lpr/0
Tg(Thy1-APPLon)2Vln/0
Genetic
Background		 involves: C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:86694 )
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

homeostasis/metabolism
amyloid beta deposits ( J:86694 )
• plaques are seen at 6 months of age
• as soon as detectable, a large number of deposits have a fibrillar conformation

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:86694

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory