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Phenotypes Associated with This Genotype
Genotype
MGI:5006847
cx11
Allelic
Composition		 Atp11cm1Btlr/Y
Tg(BCL2)22Wehi/0
Genetic
Background		 involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cm1Btlr mutation (1 available); any Atp11c mutation (16 available)
Tg(BCL2)22Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased marginal zone B cell number ( J:171925 )
• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
decreased mature B cell number ( J:171925 )
• as in Atp11cm1Btlr hemizygotes in the bone marrow
decreased follicular B cell number ( J:171925 )
• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes

hematopoietic system
increased marginal zone B cell number ( J:171925 )
• compared to in Tg(BCL2)22Wehi mice or Atp11cm1Btlr hemizygotes
decreased B cell number ( J:171925 )
• the percentage of CD19+ B cells is partially rescued compared to in Atp11cm1Btlr hemizygotes
decreased mature B cell number ( J:171925 )
• as in Atp11cm1Btlr hemizygotes in the bone marrow
decreased follicular B cell number ( J:171925 )
• follicular B cell numbers are partially rescued compared to in Atp11cm1Btlr hemizygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory