Analysis Tools
behavior/neurological
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• mice exhibit increased mechanical allodynia in the complete Freund's adjuvant model of chronic inflammatory pain compared with wild-type mice
• however, treatment with human ACPP restores normal chronic inflammatory pain
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• in the complete Freund's adjuvant model of chronic inflammatory pain and in the spared nerve injury model of neuropathic pain
• however, treatment with human ACPP restores normal chronic inflammatory pain
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endocrine/exocrine glands
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• dorsolateral prostate shows irregularities and invaginations of the basement membrane into the epithelium and an increase in number of electron-lucent enlarged vacuoles and bursting of luminal exosome-like vesicles
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• epithelial hyperplasia seen at 3 months of age in the dorsolateral prostate
• proliferation is increased in the dorsolateral prostate at 3, 6, and 12 months of age
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• prostatic epithelium loses the regular structure of uniform columnar monolayer transforming to a cuboidal multilayer epithelium with hyperchromatic nuclei and presence of pseudo-lumens
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• all mice develop prostate adenocarcinoma by 12 months of age
• at 24 months of age, mice show an increase in the amount of cells in the anterior prostate lumen and invasion of the surrounding areas, indicating locally invasive prostate adenocarcinoma, however metastatic lesions in brain, liver, lungs, and lymph nodes are not seen
• crowding of inflammatory cells is seen in sites of microinvasive adenocarcinoma
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• hyperplastic growth is seen already at 3 months of age, followed by prostatic intraepithelial neoplasia in dorsolateral and anterior prostate at 6 months and prostate adenocarcinoma at 12 months
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reproductive system
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• dorsolateral prostate shows irregularities and invaginations of the basement membrane into the epithelium and an increase in number of electron-lucent enlarged vacuoles and bursting of luminal exosome-like vesicles
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• epithelial hyperplasia seen at 3 months of age in the dorsolateral prostate
• proliferation is increased in the dorsolateral prostate at 3, 6, and 12 months of age
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• prostatic epithelium loses the regular structure of uniform columnar monolayer transforming to a cuboidal multilayer epithelium with hyperchromatic nuclei and presence of pseudo-lumens
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• all mice develop prostate adenocarcinoma by 12 months of age
• at 24 months of age, mice show an increase in the amount of cells in the anterior prostate lumen and invasion of the surrounding areas, indicating locally invasive prostate adenocarcinoma, however metastatic lesions in brain, liver, lungs, and lymph nodes are not seen
• crowding of inflammatory cells is seen in sites of microinvasive adenocarcinoma
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• hyperplastic growth is seen already at 3 months of age, followed by prostatic intraepithelial neoplasia in dorsolateral and anterior prostate at 6 months and prostate adenocarcinoma at 12 months
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neoplasm
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• all mice develop prostate adenocarcinoma by 12 months of age
• at 24 months of age, mice show an increase in the amount of cells in the anterior prostate lumen and invasion of the surrounding areas, indicating locally invasive prostate adenocarcinoma, however metastatic lesions in brain, liver, lungs, and lymph nodes are not seen
• crowding of inflammatory cells is seen in sites of microinvasive adenocarcinoma
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• hyperplastic growth is seen already at 3 months of age, followed by prostatic intraepithelial neoplasia in dorsolateral and anterior prostate at 6 months and prostate adenocarcinoma at 12 months
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| prostate cancer | DOID:10283 |
OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 |
J:207558 | |
