Phenotypes Associated with This Genotype

Genotype
MGI:5008417

• Allelic Composition: Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt; Tg(MAPT)8cPdav/0
• Genetic Background: B6.Cg-Tg(MAPT)8cPdav Mapt^tm1(EGFP)Klt/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Beta-amyloid plaques in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and neurofibrillary tangles in Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/0 mice

behavior/neurological

abnormal spatial learning ( J:172426 )

• 6 month old mutants exhibit slower visuospatial learning than control mice

• in the visuospatial re-learning test performed at 7, 8, 9, and 15 months of age, mutants exhibit a decrease in the speed of re-learning the task compared to controls

• however, mutants perform better than Tg(APPswe,PSEN1dE9)85Dbo mice on the visuospatial re-learning test at 9 and 18 months of age

taste/olfaction

taste/olfaction phenotype ( J:172426 )

N • mutants do not exhibit Alzheimer's disease-related impairment in olfactory performance in tests based on an operant conditioning procedure and in tests based on a habituation/dishabituation procedure

nervous system

neurofibrillary tangles ( J:172426 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:172426