Phenotypes Associated with This Genotype

Genotype
MGI:5008609

• Allelic Composition: Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0038_4_C09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} mice (asterisk) are smaller and show gait abnormalities

behavior/neurological

decreased anxiety-related response ( J:172582 )

• in an open field test, male mice spend more time in the center and less time along the walls compared with wild-type mice

• however, female mice do not exhibit altered behavior in an open field test

impaired coordination ( J:172582 )

• progressive

• at P90 on a rotarod in both male and female mice

jerky movement ( J:172582 )

abnormal gait ( J:172582 )

• beginning before weaning with splayed hind legs

decreased locomotor activity ( J:172582 )

• in an open field test, mice exhibit decreased total distance moved compared with wild-type mice

• however, female mice do not exhibit altered behavior in an open field test

paralysis ( J:172582 )

• mice exhibit progressive immobility and impaired motor function with spasticity and jerky movements unlike wild-type mice

nervous system

gliosis ( J:172582 )

• mice exhibit reactive gliosis unlike wild-type mice

spongiform encephalopathy ( J:172582 )

• at 4 months in hippocampus, thalamus, brainstem, cerebellum, and spinal cord

• however, mice exhibit normal white matter tracts of corpus callosum and optic nerve and dentate granule cells are spared

muscle

abnormal muscle tone ( J:172582 )

• mice exhibit a general lack of muscle tone compared with wild-type mice

muscle hypertonia ( J:172582 )

muscle weakness ( J:172582 )

• in the hind limb

growth/size/body

decreased body size ( J:172582 )

decreased body weight ( J:172582 )

• at P40

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Canavan disease		DOID:3613	OMIM:271900	J:172582