Phenotypes Associated with This Genotype

Genotype
MGI:5009036

• Allelic Composition: Ncstn^tm1.1Akli/Ncstn^tm1.1Akli; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:172442 )

• do not survive more than 20 weeks after induction of cre mediated recombination

hematopoietic system

abnormal definitive hematopoiesis ( J:172442 )

• significant reduction of the lymphoid-biased multipotential progenitor population (L-MPP) after induction of cre mediated recombination

• striking increase in the absolute numbers of both bone marrow and spleen granulocyte/monocyte progenitors cells after induction of cre mediated recombination

• decrease of the megakaryocyte?erythrocyte progenitor population after induction of cre mediated recombination

• progenitor cells display an increase in their self-renewal capacity after induction of cre mediated recombination

increased leukocyte cell number ( J:172442 )

• striking peripheral blood leukocytosis after induction of cre mediated recombination

increased monocyte cell number ( J:172442 )

• striking peripheral blood monocytosis after induction of cre mediated recombination

• increase in monocyte numbers in the bone marrow and liver after induction of cre mediated recombination

abnormal hematopoietic stem cell morphology ( J:172442 )

• de-repression of an extended myeloid-specific program in LSK cells

increased hematopoietic stem cell number ( J:172442 )

• increase in LSK numbers after induction of cre mediated recombination

abnormal spleen morphology ( J:172442 )

• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells after induction of cre mediated recombination

enlarged spleen ( J:172442 )

• after induction of cre mediated recombination

increased spleen red pulp amount ( J:172442 )

• expansion of the red pulp after induction of cre mediated recombination

neoplasm

increased leukemia incidence ( J:172442 )

• similarity to chronic myelomonocytic leukemia after induction of cre mediated recombination

immune system

increased leukocyte cell number ( J:172442 )

• striking peripheral blood leukocytosis after induction of cre mediated recombination

increased monocyte cell number ( J:172442 )

• striking peripheral blood monocytosis after induction of cre mediated recombination

• increase in monocyte numbers in the bone marrow and liver after induction of cre mediated recombination

abnormal spleen morphology ( J:172442 )

• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells after induction of cre mediated recombination

enlarged spleen ( J:172442 )

• after induction of cre mediated recombination

increased spleen red pulp amount ( J:172442 )

• expansion of the red pulp after induction of cre mediated recombination

growth/size/body

enlarged spleen ( J:172442 )

• after induction of cre mediated recombination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:172442