Phenotypes Associated with This Genotype

Genotype
MGI:5009240

cn39

• Allelic Composition: Smad1^tm1Abr/Smad1^tm1.1Abr; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: BALB/cJ * C57 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased osteoblast proliferation ( J:172689 )

• osteoblast proliferation is reduced compared to in wild-type mice

decreased osteoblast cell number ( J:172689 )

abnormal trabecular bone morphology ( J:172689 )

• mice exhibit increased trabecular separation and structural model index compared with wild-type mice

decreased trabecular bone volume ( J:172689 )

• at 2 months

decreased bone trabecula number ( J:172689 )

increased bone trabecular spacing ( J:172689 )

decreased trabecular bone connectivity density ( J:172689 )

decreased trabecular bone thickness ( J:172689 )

abnormal skeleton development ( J:172689 )

• bone formation rate is reduced compared to in wild-type mice

impaired osteoblast differentiation ( J:172689 )

• osteoblast differentiation is impaired compared to in wild-type mice

cellular

impaired osteoblast differentiation ( J:172689 )

• osteoblast differentiation is impaired compared to in wild-type mice

decreased osteoblast proliferation ( J:172689 )

• osteoblast proliferation is reduced compared to in wild-type mice