Phenotypes Associated with This Genotype

Genotype
MGI:5009245

cn2

• Allelic Composition: Etv2^tm1Dlim/Etv2^tm2.1Dlim; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

impaired myelopoiesis ( J:172687 )

• pIpC-treated mice exhibit a slightly decreased in the number of myeloid cells in the bone marrow and peripheral blood compared with control mice

decreased bone marrow cell number ( J:172687 )

• in pIpC-treated mice

abnormal myeloblast morphology/development ( J:172687 )

• pIpC-treated mice exhibit a decrease in the number of granulocyte-monocyte progenitors in the bone marrow compared with control mice

decreased leukocyte cell number ( J:172687 )

• slight in the peripheral blood of pIpC-treated mice

decreased hematopoietic stem cell number ( J:172687 )

• pIpC-treated mice exhibit reduced LSK cells, long-term hematopoietic stem cells, and short-term hematopoietic stem cells compared with control mice

spleen hypoplasia ( J:172687 )

• in pIpC-treated mice

abnormal hematopoietic stem cell physiology ( J:172687 )

• pIpC-treated mice exhibit increased apoptosis and decreased proliferation of LSK cells compared with control mice

• hematopoietic stem cells from pIpC-treated mice exhibit reduced repopulation capacity compared with cells from control mice

immune system

impaired myelopoiesis ( J:172687 )

• pIpC-treated mice exhibit a slightly decreased in the number of myeloid cells in the bone marrow and peripheral blood compared with control mice

decreased leukocyte cell number ( J:172687 )

• slight in the peripheral blood of pIpC-treated mice

spleen hypoplasia ( J:172687 )

• in pIpC-treated mice