Phenotypes Associated with This Genotype

Genotype
MGI:5009260

hm1

• Allelic Composition: Shox2^{tm2(SHOX_a)Ypc}/Shox2^{tm2(SHOX_a)Ypc}
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size of Shox2^{tm2(SHOX_a)Ypc}/Shox2^{tm2(SHOX_a)Ypc} pups

mortality/aging

postnatal lethality, complete penetrance ( J:172674 )

• expected numbers are born but none survive more than 3 days past birth

growth/size/body

decreased birth body size ( J:172674 )

decreased birth weight ( J:172674 )

cardiovascular system

decreased heart rate ( J:172674 )

• at P1

irregular heartbeat ( J:172674 )

• at P1

craniofacial

craniofacial phenotype ( J:172674 )

N • expression of human SHOX_a rescues the cleft palate seen in null mice