Phenotypes Associated with This Genotype

Genotype
MGI:5009549

• Allelic Composition: Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased neuroblastoma incidence ( J:41126 )

• mutants develop thoracic paraspinous masses that histology indicates as neuroblastomas

• tumors show varying degrees of neuronal differentiation

• tumors show gains and losses of chromosomal regions; most commonly gained regions are on chromosomes 11 and 17, while loss is associated most often with chromosomes 5, 9, 16 and X

• Background Sensitivity: tumor penetrance on a background involving BALB/c and C57BL/6J is greater than in mutants with a BALB/c, C57BL/6J and FVB/N background

nervous system

increased neuroblastoma incidence ( J:41126 )

• mutants develop thoracic paraspinous masses that histology indicates as neuroblastomas

• tumors show varying degrees of neuronal differentiation

• tumors show gains and losses of chromosomal regions; most commonly gained regions are on chromosomes 11 and 17, while loss is associated most often with chromosomes 5, 9, 16 and X

• Background Sensitivity: tumor penetrance on a background involving BALB/c and C57BL/6J is greater than in mutants with a BALB/c, C57BL/6J and FVB/N background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:41126