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Phenotypes Associated with This Genotype
Genotype
MGI:5009554
Allelic
Composition		 Tg(Th-MYCN)41Waw/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-MYCN)41Waw mutation (2 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased neuroblastoma incidence ( J:41126 )
• mutants exhibit a tumor incidence similar to that of single hemizygous Tg(Th-MYCN)41Waw mice

nervous system
increased neuroblastoma incidence ( J:41126 )
• mutants exhibit a tumor incidence similar to that of single hemizygous Tg(Th-MYCN)41Waw mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
neuroblastoma DOID:769 J:41126

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory