Phenotypes Associated with This Genotype

Genotype
MGI:5009555

• Allelic Composition: Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histology and immunohistochemistry of neuroblastoma Tg(Th-MYCN)41Waw/0 tumors

neoplasm

increased neuroblastoma incidence ( J:172448 )

• about 33% of mutants develop neuroblastoma in the paraspinal ganglia, but not in the adrenal

• tumors are first detected in the abdomen at 6 weeks of age and arise in the ganglion cells

• tumors show features of neuronal differentiation including dense core neurosecretory vesicles, synaptic junctions and areas of lipids throughout the tumors

• neuroblastomas resemble a class of aggressive human neuroblastoma tumors classified as large cell neuroblastoma and have molecular and cellular features of Stage 4 NMYC amplified human neuroblastoma

• 10% of tumors exhibit an arrest in growth between weeks 8-10 which last about 2 weeks and is followed by complete regression of tumors

nervous system

increased neuroblastoma incidence ( J:172448 )

• about 33% of mutants develop neuroblastoma in the paraspinal ganglia, but not in the adrenal

• tumors are first detected in the abdomen at 6 weeks of age and arise in the ganglion cells

• tumors show features of neuronal differentiation including dense core neurosecretory vesicles, synaptic junctions and areas of lipids throughout the tumors

• neuroblastomas resemble a class of aggressive human neuroblastoma tumors classified as large cell neuroblastoma and have molecular and cellular features of Stage 4 NMYC amplified human neuroblastoma

• 10% of tumors exhibit an arrest in growth between weeks 8-10 which last about 2 weeks and is followed by complete regression of tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:172448