Phenotypes Associated with This Genotype

Genotype
MGI:5009703

• Allelic Composition: Ar^tm1Verh/Y; Pten^tm1Hwu/Pten^tm1Hwu; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:172730 )

♂ • mutants develop adenocarcinoma in the dorsolateral lobes of the prostate

♂ • cancer progression is similar to single conditional Pten mice

♂ • proliferation and apoptotic indexes are increased in the cancers, most notably in the proximal regions of the dorsal-lateral lobe

♂ • mutant tumors contain low or no p63+ cells, similar to human prostate cancer

♂ • castrated mutants develop cancer outgrowths in the dorsolateral lobes, indicating that mutants develop castrate-resistant prostate cancer

♂ • castrated mice treated with rapamycin show a reduction in prostate volume and reduced prostate proliferation

reproductive system

increased prostate gland adenocarcinoma incidence ( J:172730 )

♂ • mutants develop adenocarcinoma in the dorsolateral lobes of the prostate

♂ • cancer progression is similar to single conditional Pten mice

♂ • proliferation and apoptotic indexes are increased in the cancers, most notably in the proximal regions of the dorsal-lateral lobe

♂ • mutant tumors contain low or no p63+ cells, similar to human prostate cancer

♂ • castrated mutants develop cancer outgrowths in the dorsolateral lobes, indicating that mutants develop castrate-resistant prostate cancer

♂ • castrated mice treated with rapamycin show a reduction in prostate volume and reduced prostate proliferation

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:172730 )

♂ • mutants develop adenocarcinoma in the dorsolateral lobes of the prostate

♂ • cancer progression is similar to single conditional Pten mice

♂ • proliferation and apoptotic indexes are increased in the cancers, most notably in the proximal regions of the dorsal-lateral lobe

♂ • mutant tumors contain low or no p63+ cells, similar to human prostate cancer

♂ • castrated mutants develop cancer outgrowths in the dorsolateral lobes, indicating that mutants develop castrate-resistant prostate cancer

♂ • castrated mice treated with rapamycin show a reduction in prostate volume and reduced prostate proliferation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:172730