Phenotypes Associated with This Genotype

Genotype
MGI:5014212

• Allelic Composition: Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal microglial cell morphology ( J:132679 )

• induction increases microglia numbers by about 17%

abnormal microglial cell activation ( J:132679 )

• following induction, local microglial activation in the substantia nigra and striatum but not in the cortex

abnormal dopaminergic neuron morphology ( J:132679 )

• following induction of transgene expression surviving tyrosine hydroxylase positive cells in mesencephalic cultures prepared from E14 embryos show significant loss of neurite processes

loss of dopaminergic neurons ( J:132679 )

• induction of transgene expression results in significant loss of tyrosine hydroxylase positive cells in mesencephalic cultures prepared from E14 embryos

• a 2 week induction period results in a 40% loss of dopaminergic neurons in the substantia nigra

• loss of dopaminergic neurons is prevented by deprenyl co-treatment

• removal of doxycycline from the feed does not reverse cell loss

neurodegeneration ( J:132679 )

• irreversible dopaminergic substantia nigra neurodegeneration following induction of transgene expression

abnormal neuron physiology ( J:132679 )

• following induction elevated levels of H2O2 are found in the media of cultures of mesencephalic cultures

• H2O2 levels are elevated in isolated ST dopaminergic synaptosomes following induction of transgene expression

• elevated levels of mitochondrial O2- levels in dopaminergic neurons following induction

behavior/neurological

decreased locomotor activity ( J:132679 )

• locomotor activity is reduced following 2 weeks of doxycycline treatment

hematopoietic system

abnormal microglial cell morphology ( J:132679 )

• induction increases microglia numbers by about 17%

abnormal microglial cell activation ( J:132679 )

• following induction, local microglial activation in the substantia nigra and striatum but not in the cortex

immune system

abnormal microglial cell morphology ( J:132679 )

• induction increases microglia numbers by about 17%

abnormal microglial cell activation ( J:132679 )

• following induction, local microglial activation in the substantia nigra and striatum but not in the cortex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:132679