Phenotypes Associated with This Genotype

Genotype
MGI:5014310

• Allelic Composition: Tg(Upk2-TAg)1Rkl/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Urothelial carcinoma in situ in Tg(Upk2-TAg)1Rkl/0 mice

neoplasm

abnormal tumor vascularization ( J:173505 )

• tumors develop prominent vasculature

• tumors exhibit hypoxia

• however, pericyte coverage is normal

abnormal metastatic potential ( J:173505 )

• one mouse exhibited lamina propria invasion

increased urinary bladder carcinoma incidence ( J:173505 )

• all mice develop bladder urothelial carcinoma in situ

• male mice develop higher bladder weight due to higher tumor burden compared with female mice

increased urinary bladder transitional cell carcinoma incidence ( J:173505 )

• a flat growth with large and pleomorphic nuclei and frequent mitoses

renal/urinary system

increased urinary bladder carcinoma incidence ( J:173505 )

• all mice develop bladder urothelial carcinoma in situ

• male mice develop higher bladder weight due to higher tumor burden compared with female mice

increased urinary bladder transitional cell carcinoma incidence ( J:173505 )

• a flat growth with large and pleomorphic nuclei and frequent mitoses

increased urinary bladder weight ( J:173505 )

• male mice develop higher bladder weight due to higher tumor burden compared with female mice

homeostasis/metabolism

hypoxia ( J:173505 )

• tumors exhibit hypoxia

cardiovascular system

abnormal tumor vascularization ( J:173505 )

• tumors develop prominent vasculature

• tumors exhibit hypoxia

• however, pericyte coverage is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:173505