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Phenotypes Associated with This Genotype
Genotype
MGI:5014516
Allelic
Composition		 Krastm4Tyj/Kras+
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased ovary tumor incidence ( J:161953 )
• mutants injected with an adenoviral Cre into the right ovarian bursa to induce recombination develop ovarian cancer eight weeks after injection

reproductive system
increased ovary tumor incidence ( J:161953 )
• mutants injected with an adenoviral Cre into the right ovarian bursa to induce recombination develop ovarian cancer eight weeks after injection

endocrine/exocrine glands
increased ovary tumor incidence ( J:161953 )
• mutants injected with an adenoviral Cre into the right ovarian bursa to induce recombination develop ovarian cancer eight weeks after injection

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:161953

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory