Phenotypes Associated with This Genotype

Genotype
MGI:5051942

• Allelic Composition: Apoa4^tm1Bres/Apoa4^tm1Bres; Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:169682 )

• impaired survival compared to wild-type mice and transgenic mice wild-type for Apoa4

nervous system

amyloid beta deposits ( J:169682 )

• accelerated deposition compared to transgenic mice wild-type for Apoa4

neuron degeneration ( J:169682 )

• large pyramidal neurons in cortical layer 5 and neurons in hippocampus contain more disrupted morphologies indicating enhanced neuron loss compared to transgenic mice wild-type for Apoa4

• loss of neurons is increased in areas of the cortex and CA1, CA3 of the hippocampus

behavior/neurological

abnormal spatial learning ( J:169682 )

• impaired spatial learning (slower decrease in escape latency during training in a morris water maze) compared to transgenic mice wild-type for Apoa4

abnormal long-term spatial reference memory ( J:169682 )

• more time spent in the incorrect quadrant in a probe trial in a morris water maze compared to transgenic mice wild-type for Apoa4

homeostasis/metabolism

amyloid beta deposits ( J:169682 )

• accelerated deposition compared to transgenic mice wild-type for Apoa4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:169682