Phenotypes Associated with This Genotype

Genotype
MGI:5051961

hm1

• Allelic Composition: Kdm4d^tm1Zuk/Kdm4d^tm1Zuk
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:173703 )

N • male mice exhibit normal fertility

abnormal spermatid morphology ( J:173703 )

♂ • spermatids exhibit an accumulation of histone 3 methylation (H3K9me3) compared to in wild-type cells

abnormal male germ cell apoptosis ( J:173703 )

♂ • occasionally in testes of mice older than 10 weeks at low frequencies

enlarged seminiferous tubules ( J:173703 )

♂ • wider diameter at 3 weeks but not in older mice

enlarged testis ( J:173703 )

♂ • transiently at 12 weeks

growth/size/body

decreased body weight ( J:173703 )

• at 16 and 52 weeks of age

endocrine/exocrine glands

enlarged seminiferous tubules ( J:173703 )

♂ • wider diameter at 3 weeks but not in older mice

enlarged testis ( J:173703 )

♂ • transiently at 12 weeks

cellular

abnormal spermatid morphology ( J:173703 )

♂ • spermatids exhibit an accumulation of histone 3 methylation (H3K9me3) compared to in wild-type cells

abnormal male germ cell apoptosis ( J:173703 )

♂ • occasionally in testes of mice older than 10 weeks at low frequencies