Phenotypes for Fgf23 Sfrp4 MGI:5052063 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fgf23^tm1Blan/Fgf23^tm1Blan Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf23^tm1Blan mutation (0 available); any Fgf23 mutation (19 available)
Sfrp4^tm1.1Blan mutation (0 available); any Sfrp4 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:173962 )

• average life span is 8 to 12 weeks

homeostasis/metabolism

increased circulating phosphate level ( J:173962 )

renal/urinary system

nephrocalcinosis ( J:173962 )

respiratory system

emphysema ( J:173962 )

digestive/alimentary system

abnormal digestive system morphology ( J:173962 )

• mice exhibit intestinal atrophy unlike wild-type mice

cardiovascular system

calcified artery ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 3 and 6 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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