Phenotypes Associated with This Genotype

Genotype
MGI:5052112

• Allelic Composition: Tg(Mapt-MAPT*)#Hanr/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:137947 )

• plaque like structures are detected but no amyloid beta protein is detected in these plaques

neurofibrillary tangles ( J:137947 )

• are detected in the cortex, hippocampus and brainstem at 6 months of age and to a greater extent at 9 months of age

tau protein deposits ( J:137947 )

• at 10 months of age

astrocytosis ( J:137947 )

• in the cortex, hippocampus and brainstem at 6 months of age and to a greater extent at 9 months of age

abnormal long-term potentiation ( J:137947 )

• able to induce short term potentiation but unable to maintain it

decreased paired-pulse facilitation ( J:137947 )

• at 60 ms inter-stimulus intervals

behavior/neurological

behavior/neurological phenotype ( J:137947 )

N • do not display any gross motor defects

abnormal spatial learning ( J:137947 )

• at 6-7 months of age, perform worse in an 8 arm maze over 5 days of training

• deficits remain at 9 months of age

abnormal long-term spatial reference memory ( J:137947 )

• at 6-7 months of age, perform worse in an 8 arm maze over 5 days of training

• deficits remain at 9 months of age

increased anxiety-related response ( J:137947 )

• defecate and urinate excessively in an 8 arm maze suggesting an increase in anxiety

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:137947
tauopathy		DOID:680		J:137947