Phenotypes Associated with This Genotype

Genotype
MGI:5052307

• Allelic Composition: Cnr1^tm1Map/Cnr1^tm1Map; Tg(HD82Gln)81Gschi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:172874 )

• reduced lifespan compared to wild-type controls

• however lifespan is similar to transgenic mice wild-type for Cnr1

nervous system

abnormal striatum morphology ( J:172874 )

• increase in the density of ubiquitin positive aggregates in the striatum compared to transgenic mice wild-type for Cnr1

behavior/neurological

impaired coordination ( J:172874 )

• reduced latency to fall and an increased number of falls in a rotarod assay

• motor performance is worse than in transgenic mice wild-type for Cnr1

growth/size/body

decreased body weight ( J:172874 )

• fail to gain weight after 16 weeks of age

abnormal postnatal growth ( J:172874 )

• fail to gain weight after 16 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:172874