nervous system
N |
• unlike in mice carrying Tg(JPH3*)CXwy no signs of neurodegeneration are detected at 12 months of age
|
• diffuse accumulation of polyQ nuclear inclusions are detected in the striatum
|
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
|
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
|
• progressive formation of polyQ nuclear inclusions between 6 and 14 months of age
• inclusions are particularly abundant in the cortex and hippocampus with diffuse accumulation also detected in the striatum
|
behavior/neurological
• impaired motor learning in a rotarod assay at 12 months of age
|
• at 12 months of age in a rotarod assay
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Huntington's disease-like 2 | DOID:0090104 |
OMIM:606438 |
J:174267 |