mortality/aging
• median survival is 21 weeks
• all die by 25 weeks of age
|
nervous system
• progression of neuropathology is more rapid compared to mice carrying Tg(HTT*/EGFP)150Nn
|
behavior/neurological
• chorea-like movements
• show irregular, jerky involuntary head movements at about 8 weeks of age
|
• rare
|
• progressive development of an ataxic gait that is severe and interferes with walking by 16 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Huntington's disease | DOID:12858 |
OMIM:143100 |
J:174269 |