Phenotypes Associated with This Genotype

Genotype
MGI:5085920

• Allelic Composition: Lrrtm1^tm1.1Jaru/Lrrtm1^tm1.1Jaru
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Approach toward inanimate objects is altered in Lrrtm1^tm1.1Jaru/Lrrtm1^tm1.1Jaru mice

behavior/neurological

enhanced contextual conditioning behavior ( J:174350 )

• mice exhibit increased freezing compared with wild-type mice

enhanced cued conditioning behavior ( J:174350 )

• mice exhibit increased freezing compared with wild-type mice

abnormal spatial working memory ( J:174350 )

• a Morris water maze, mice exhibit poorer performance with increased diving and rearing compared with wild-type mice

abnormal emotion/affect behavior ( J:174350 )

• in an elevated plus maze, mice spend more times in the open arms, enter open arms more, and produce more fecal droppings compared with wild-type mice

• on a circle platform, mice exhibit increased freezing compared with wild-type mice

• in an open-field test, mice spend less time with a large object compared with wild-type mice

• in a home cage, mice make less contact with small objects compared with wild-type mice

• in a social discrimination test, mice avoid approaching an empty cage during the first exposure in the habituation session unlike wild-type mice

• fluoxetine-treated mice exhibit less time in the open arms of an elevated plus maze compared with untreated mice but more than a similarly treated wild-type mice

• however, mice make normal contact with a small object in an open-field and exhibit normal preference for a novel object

decreased exploration in new environment ( J:174350 )

• in a light-dark box transition test, mice exhibit increased latency to entering the dark box and make few transitions compared with wild-type mice

• in an open-field test with four holes, mice exhibit prolonged latency to first head dip compared with wild-type mice

increased thigmotaxis ( J:174350 )

• mice spend more time in the corners of an open-field compared with wild-type mice

increased vertical activity ( J:174350 )

• in a Morris water maze

decreased locomotor activity ( J:174350 )

• in young mice under bright illumination (250 lx) in an open-field box

• in 8 month old mice in several behavioral tests under darker conditions (70 lx)

abnormal social investigation ( J:174350 )

• in a social discrimination test, mice contact the familiar mice more than wild-type mice

nervous system

small hippocampus ( J:174350 )

• detected by MRI

thin cerebral cortex ( J:174350 )

• slight

increased dendritic spine length ( J:174350 )

• spine length in the hippocampus is increased compared to in wild-type mice

• however, mice exhibit normal width and density of the dendritic spines

abnormal synapse morphology ( J:174350 )

• synaptic density in the stratum radiatum is reduced compared to in wild-type mice

• however, mice exhibit normal postsynaptic density (PSD) length, PSD thickness, and synaptic cleft size

abnormal synaptic vesicle morphology ( J:174350 )

• mice exhibit an increase in mean inter-vesicular distance in the stratum radiatum and stratum oriens compared with wild-type mice

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:174350 )

• MK801-treated mice exhibit increased episodes of moving, decreased duration of single movements, and increased contact with a large object compared with similarly treated wild-type mice

• fluoxetine-treated mice exhibit less time in the open arms of an elevated plus maze compared with untreated mice but more than a similarly treated wild-type mice

• however, mice exhibit normal response to clozapine treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:174350