Analysis Tools
mortality/aging
homeostasis/metabolism
cardiovascular system
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• dramatic overgrowth
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growth/size/body
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• dramatic overgrowth
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• kidneys that do form are significantly enlarged
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renal/urinary system
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• kidneys may display agenesis or over growth, with both conditions often seen in the same animal
• unilateral or bilateral renal agenesis is seen in 64% of mice
• kidneys that do form have an expanded population of mesenchymal progenitor cells
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• kidneys that do form are significantly enlarged
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• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice
• absence of ureteric bud derived structures at E13.5 in some mice
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• expression analysis indicates that the metanephric mesenchyme is specified but fails to condense and undergo epithelialization
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• widespread apoptosis is seen in many mice
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• absence of ureteric bud derived structures at E13.5 in some mice
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embryo
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• widespread apoptosis is seen in many mice
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• the Wolffian duct remains detached from the ureteric bud at E13.5 in some mice
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skeleton
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• dramatic bone overgrowth
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• malformation of the postnatal suture
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• abnormally distant ossification fronts in the perinatal cranial vault
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• enlarged cranial vault
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• discontinuous cortical bone layer at E15.5
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• malformed or absent
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bowed radius
(
J:173242
)
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• enlarged radius
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• enlarged and bowed
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bowed ulna
(
J:173242
)
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• massive increases in mineralized matrix
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• decreased mineralization of the trabecular area in long bones perinatally
• massive increases in mineralized matrix in the compact bone
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• deficiency in endochondral bone ossification
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• asymmetrical distribution of ossification centers
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• delayed ossification of the long bones at E14.5
• discontinuous cortical bone layer in long bones at E15.5
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• deficiency in intramembranous bone ossification
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• abnormally distant ossification fronts in the perinatal cranial vault
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adipose tissue
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• severely reduced
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• severely reduced
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• hypoplastic adipose tissue
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hematopoietic system
immune system
craniofacial
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• malformation of the postnatal suture
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• abnormally distant ossification fronts in the perinatal cranial vault
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• enlarged cranial vault
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limbs/digits/tail
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• malformed or absent
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bowed radius
(
J:173242
)
|
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• enlarged radius
|
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• enlarged and bowed
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bowed ulna
(
J:173242
)
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cellular
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• widespread apoptosis is seen in many mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| osteopathia striata with cranial sclerosis | DOID:0060886 |
OMIM:300373 |
J:173242 | |
