Phenotypes Associated with This Genotype

Genotype
MGI:5086118

• Allelic Composition: Amelx^tm1Kul/Amelx^tm1Kul; Tg(AMELX*P70T)2Gibs/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

♀ • tumor is composed of benign, eosinophilic, polygonal-shaped cells with intercellular bridges

♀ • calcification is not obvious in these tumors

craniofacial

abnormal enamel morphology ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

growth/size/body

abnormal enamel morphology ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

skeleton

abnormal enamel morphology ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amelogenesis imperfecta type 1E		DOID:0110058	OMIM:301200	J:122914