Phenotypes Associated with This Genotype

Genotype
MGI:5140544

cn1

• Allelic Composition: Cacna1a^tm1Kano/Cacna1a^tm1Kano; Grid2^tm1(cre)Mwa/Grid2⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron morphology ( J:173318 )

• regression of surplus climbing fibers (CFs) is severely impaired compared to in control mice

• from P5 to P7, the bias toward strengthening single CFs is impaired compared to in control mice

• multiple CFs translocate to dendrites and impairs elimination of CF synapses from the soma unlike in control cells

abnormal CNS synaptic transmission ( J:173318 )

• at P5 to P6, Purkinje cells (PCs) in cerebellar slices exhibit reduced calcium currents compared with control cells

• PCs lack P/Q-type voltage-dependent calcium channel (VDCC) compared with control cells

• climbing fiber (CF)-induced calcium transients in PCs are reduced compared to in control cells

• however, mice exhibit normal P/Q channel contribution to CF to PC synaptic transmission and spontaneous inhibitory postsynaptic currents at P6 to P7 and P10

abnormal excitatory postsynaptic currents ( J:173318 )

• from P5 to P8, the fractions of multiple CF-EPSCs remains unchanged unlike in control mice

prolonged excitatory postsynaptic current decay time ( J:173318 )

• in climbing fiber cells

prolonged excitatory postsynaptic current rise time ( J:173318 )

• in climbing fiber cells