Phenotypes Associated with This Genotype

Genotype
MGI:5140739

• Allelic Composition: Ts(16C-tel)1Cje/0
• Genetic Background: involves: C57BL/6J * Rb(11.16)2H * Rb(16.17)32Lub

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lymphoma incidence ( J:174270 )

• malignant lymphoma in the spleen and lymph nodes is observed in some mutants

• megakaryocytes are numerous is some spleens, suggesting a relation to megakaryocytic leukemia

increased follicular lymphoma incidence ( J:174270 )

• splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma

cellular

abnormal neuron differentiation ( J:241597 )

• neurogenesis is decreased about 39.1% and 42.7% in the subventricular zone and the dentate gyrus, respectively

immune system

abnormal spleen red pulp morphology ( J:174270 )

• splenic red pulp is largely obliterated

abnormal spleen B cell follicle morphology ( J:174270 )

• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles

abnormal spleen B cell follicle shape ( J:241597 )

• irregular

increased spleen B cell follicle size ( J:241597 )

nervous system

abnormal neuron differentiation ( J:241597 )

• neurogenesis is decreased about 39.1% and 42.7% in the subventricular zone and the dentate gyrus, respectively

dilated lateral ventricle ( J:241597 )

• lateral brain ventricle volumes are larger at 3 months of age, increased by 58.5%

• other (3rd and 4th) ventricles show trends of enlargement

• however, whole brain volume is normal

hematopoietic system

abnormal spleen red pulp morphology ( J:174270 )

• splenic red pulp is largely obliterated

abnormal spleen B cell follicle morphology ( J:174270 )

• splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles

abnormal spleen B cell follicle shape ( J:241597 )

• irregular

increased spleen B cell follicle size ( J:241597 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:174270 , J:241597