Phenotypes Associated with This Genotype

Genotype
MGI:5141741

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Fgfr3^tm4Cxd/Fgfr3⁺; Tg(Upk2-cre)6Xrw/0
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174242 )

• shorter survival due to lung cancer, with a survival time between 200-400 days

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:174242 )

• 100% of mutants exhibit areas of hyperproliferation in the bladder urothelium from about 3 months of age, however these lesions do not progress further when examined at 12 months of age

neoplasm

neoplasm ( J:174242 )

N • despite hyperproliferation in the bladder, mutants do not develop urothelial carcinoma by 12 months of age

N • mutants do not develop skin papillomas

increased lung tumor incidence ( J:174242 )

• 36% of mutants develop lung tumors by 1 year of age

• lung tumors resemble solitary fibrous tumors of the lugs (hemangiopericytomas)

respiratory system

increased lung tumor incidence ( J:174242 )

• 36% of mutants develop lung tumors by 1 year of age

• lung tumors resemble solitary fibrous tumors of the lugs (hemangiopericytomas)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:174242