Phenotypes Associated with This Genotype

Genotype
MGI:5141744

• Allelic Composition: Tg(UPII-SV40T)2Xrw/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased urinary bladder carcinoma incidence ( J:56305 )

• mutants succumb to bladder cancer at 3 months of age, developing patches of bladder carcinoma in situ (CIS)

increased urinary bladder transitional cell carcinoma incidence ( J:56305 )

• mutants also develop moderately differentiated transitional cell carcinoma (TCC) that invades into the detrusor muscle layer

renal/urinary system

increased urinary bladder carcinoma incidence ( J:56305 )

• mutants succumb to bladder cancer at 3 months of age, developing patches of bladder carcinoma in situ (CIS)

increased urinary bladder transitional cell carcinoma incidence ( J:56305 )

• mutants also develop moderately differentiated transitional cell carcinoma (TCC) that invades into the detrusor muscle layer

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:56305