Phenotypes Associated with This Genotype

Genotype
MGI:5141747

• Allelic Composition: Tg(UPII-SV40T)29Xrw/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:56305 )

• micrometastases are seen in the pelvic lymph nodes and lingular lobe of the liver

increased urinary bladder carcinoma incidence ( J:56305 )

• mutants succumb to bladder cancer at 5 months of age

• all mice examined at 1-2 months of age exhibit only bladder carcinoma in situ (CIS) changes, but by 5 months of age, invasive and metastatic transitional cell carcinoma (TCC) is seen

increased urinary bladder transitional cell carcinoma incidence ( J:56305 )

• mutants develop a palpable abdominal tumor at 5 months of age, with histology identifying it as a poorly differentiated transitional cell carcinoma (TCC)

renal/urinary system

increased urinary bladder carcinoma incidence ( J:56305 )

• mutants succumb to bladder cancer at 5 months of age

• all mice examined at 1-2 months of age exhibit only bladder carcinoma in situ (CIS) changes, but by 5 months of age, invasive and metastatic transitional cell carcinoma (TCC) is seen

increased urinary bladder transitional cell carcinoma incidence ( J:56305 )

• mutants develop a palpable abdominal tumor at 5 months of age, with histology identifying it as a poorly differentiated transitional cell carcinoma (TCC)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
urinary bladder cancer		DOID:11054	OMIM:109800	J:56305