Phenotypes Associated with This Genotype

Genotype
MGI:5284841

• Allelic Composition: Etv6^{tm1.1(RUNX1,hsb5)Lvdw}/Etv6⁺; TgTn(sb-T2/Onc)76Dla/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174866 )

• mice exhibit increased decreased survival compared with control mice

neoplasm

increased leukemia incidence ( J:174866 )

• mice exhibit increased incidence of leukemia compared with control mice

• predominantly acute myeloid leukemia (AML; 46%) with some T cell acute lymphocytic leukemia (T-ALL; 28%) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL; 21%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:174866