Phenotypes Associated with This Genotype

Genotype
MGI:5285220

• Allelic Composition: Bsnd^tm1.1Suc/Bsnd^tm1.1Suc
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:175265 )

N • mice fed a normal diet exhibit normal urine and blood homeostasis

increased circulating bicarbonate level ( J:175265 )

• when fed a low-salt diet

hypokalemia ( J:175265 )

• mild when fed a low-salt diet

decreased circulating sodium level ( J:175265 )

• when fed a low-salt diet

decreased circulating chloride level ( J:175265 )

• when fed a low-salt diet

decreased urine sodium level ( J:175265 )

• mild when fed a low-salt diet

alkalosis ( J:175265 )

• mild metabolic alkalosis when fed a low-salt diet

decreased physiological sensitivity to xenobiotic ( J:175265 )

• in vivo clearance of hydrochlorothiazide (HCT) is blunted compared to in wild-type mice

• however, clearance of furosemide is normal

renal/urinary system

decreased urine sodium level ( J:175265 )

• mild when fed a low-salt diet

abnormal kidney physiology ( J:175265 )

• in vitro, the thin ascending limb of Henle's loop exhibits decreased steady-state and 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB)-sensitive chloride diffusion voltage compared to in wild-type tissue

• however, the thick ascending limb of Henle's loops exhibits normal steady-state and NPPB-sensitive chloride diffusion voltage

polyuria ( J:175265 )

• mild when fed a low-salt diet

cardiovascular system

decreased systemic arterial blood pressure ( J:175265 )

• when fed a low-salt diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bartter disease type 4a		DOID:0110145	OMIM:602522	J:175265