Analysis Tools
mortality/aging
|
• median survival of 118 day
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neoplasm
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• increased levels of proliferation and DNA damage are seen in lung tissue affected by lymphoma
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• lymphomas are more aggressive and most commonly infiltrate the lungs, liver and spleen with less frequent infiltration of the colon and kidney
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• develop aggressive and widespread lymphomas involving the lung, liver, thymus, bone marrow and peripheral blood with a significantly reduced latency compared to mice null for Trp53 alone
• about 86% of mice develop lymphomas
• seldom localized to the thymus
• most commonly infiltrate the lungs, liver and spleen with less frequent infiltration of the colon and kidney
• lymphoma cells often completely deplete the lungs, liver and spleen completely obscuring the normal anatomy of these tissues
• significant invasion of the bone marrow is seen
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• develop carcinomas in various organs with a significantly reduced latency compared to mice null for Trp53 alone
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hematopoietic system
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• in pre-neoplastic splenocytes
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• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age
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• increased proliferation in pre-neoplastic bone marrow cells
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cellular
aneuploidy
(
J:174926
)
|
• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age
|
|
• in pre-neoplastic splenocytes
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immune system
|
• in pre-neoplastic splenocytes
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• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| lymphoma | DOID:0060058 | J:174926 | ||
