Phenotypes Associated with This Genotype

Genotype
MGI:5285700

• Allelic Composition: Espl1^Gt(XL058)Byg/Espl1⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: B6.129-Trp53^tm1Tyj Espl1^Gt(XL058)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174926 )

• median survival of 118 day

neoplasm

abnormal tumor pathology ( J:174926 )

• increased levels of proliferation and DNA damage are seen in lung tissue affected by lymphoma

increased metastatic potential ( J:174926 )

• lymphomas are more aggressive and most commonly infiltrate the lungs, liver and spleen with less frequent infiltration of the colon and kidney

increased lymphoma incidence ( J:174926 )

• develop aggressive and widespread lymphomas involving the lung, liver, thymus, bone marrow and peripheral blood with a significantly reduced latency compared to mice null for Trp53 alone

• about 86% of mice develop lymphomas

• seldom localized to the thymus

• most commonly infiltrate the lungs, liver and spleen with less frequent infiltration of the colon and kidney

• lymphoma cells often completely deplete the lungs, liver and spleen completely obscuring the normal anatomy of these tissues

• significant invasion of the bone marrow is seen

increased carcinoma incidence ( J:174926 )

• develop carcinomas in various organs with a significantly reduced latency compared to mice null for Trp53 alone

hematopoietic system

increased splenocyte proliferation ( J:174926 )

• in pre-neoplastic splenocytes

abnormal splenocyte morphology ( J:174926 )

• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age

abnormal bone marrow cell physiology ( J:174926 )

• increased proliferation in pre-neoplastic bone marrow cells

cellular

aneuploidy ( J:174926 )

• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age

increased splenocyte proliferation ( J:174926 )

• in pre-neoplastic splenocytes

immune system

increased splenocyte proliferation ( J:174926 )

• in pre-neoplastic splenocytes

abnormal splenocyte morphology ( J:174926 )

• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphoma		DOID:0060058		J:174926