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Phenotypes Associated with This Genotype
Genotype
MGI:5285827
cn7
Allelic
Composition		 Lgr4tm1.1Knis/Lgr4tm1.1Knis
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr4tm1.1Knis mutation (0 available); any Lgr4 mutation (94 available)
Tg(Cyp1a1-cre)1Dwi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:174842 )
• in beta-napthoflavone-treated mice

digestive/alimentary system
abnormal small intestinal crypt cell proliferation ( J:174842 )
• beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice
decreased small intestinal villus size ( J:174842 )
• in beta-napthoflavone-treated mice

cellular
abnormal small intestinal crypt cell proliferation ( J:174842 )
• beta-napthoflavone-treated mice exhibit a loss of crypt width with loss of crypt stem cells and proliferating progenitors compared with control mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory