Phenotypes Associated with This Genotype

Genotype
MGI:5286080

• Allelic Composition: Nf1^tm1Tyj/Nf1⁺; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: (CAST/EiJ x B6.129S2-Trp53^tm1Tyj Nf1^tm1Tyj/+ +)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased glioblastoma incidence ( J:64364 )

increased brain tumor incidence ( J:64364 )

• brain tumors range from diffuse cells with nuclear atypia to glioblastoma multiforme

• Background Sensitivity: mice on a congenic C57BL/6 or C3H/HeJ F1 background develop more brain tumors compared with mice on a CAST/EiJ or SJL/J F1 background

increased astrocytoma incidence ( J:64364 )

mortality/aging

decreased tumor-free survival time ( J:64364 )

• in mice with advanced tumors

neoplasm

increased glioblastoma incidence ( J:64364 )

increased brain tumor incidence ( J:64364 )

• brain tumors range from diffuse cells with nuclear atypia to glioblastoma multiforme

• Background Sensitivity: mice on a congenic C57BL/6 or C3H/HeJ F1 background develop more brain tumors compared with mice on a CAST/EiJ or SJL/J F1 background

increased astrocytoma incidence ( J:64364 )

behavior/neurological

ataxia ( J:64364 )

• in mice with advanced tumors

paralysis ( J:64364 )

• in mice with advanced tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant astrocytoma		DOID:3069		J:64364