Phenotypes Associated with This Genotype

Genotype
MGI:5286094

• Allelic Composition: Pten^tm2.1Ppp/Pten^tm2.1Ppp; Tg(GFAP-TAg121)1Tvd/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain vasculature morphology ( J:99385 )

• mice infected with a cre-expression virus exhibit increased angiogenesis in the cerebral cortex compared to in control mice

abnormal astrocyte apoptosis ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

increased astrocytoma incidence ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

neoplasm

increased astrocytoma incidence ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

cardiovascular system

abnormal brain vasculature morphology ( J:99385 )

• mice infected with a cre-expression virus exhibit increased angiogenesis in the cerebral cortex compared to in control mice

increased angiogenesis ( J:99385 )

• in cerebral cortex injected with cre-expressing virus

cellular

abnormal astrocyte apoptosis ( J:99385 )

• mice infected with a cre-expression virus exhibit astrocytmoa with increased invasiveness compared with mice expressing Tg(GFAP-TAg121)1Tvd

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant astrocytoma		DOID:3069		J:99385